CNN) -- Massachusetts Sen. Edward Kennedy, the patriarch of the first family of Democratic politics, died Wednesday at his home in Hyannis Port, Massachusetts, after a lengthy battle with brain cancer. He was 77.

Massachusetts Sen. Ted Kennedy, known as the "Lion of the Senate," died Wednesday at 77.

"We've lost the irreplaceable center of our family and joyous light in our lives, but the inspiration of his faith, optimism and perseverance will live on in our hearts forever," a family statement said. "We thank everyone who gave him care and support over this last year, and everyone who stood with him for so many years in his tireless march for progress toward justice."

Kennedy, nicknamed "Ted," was the younger brother of slain President John F. Kennedy and New York Sen. Robert Kennedy, who was gunned down while seeking the White House in 1968. However, his own presidential aspirations were hobbled by the controversy around a 1969 auto accident that left a young woman dead, and a 1980 primary challenge to then-President Jimmy Carter that ended in defeat.

But while the White House eluded his grasp, the longtime Massachusetts senator was considered one of the most effective legislators of the past few decades. Kennedy, who became known as the "Lion of the Senate," played major roles in passage of the Civil Rights Act of 1964, the Voting Rights Act of 1965, the 1990 Americans with Disabilities Act and the 1993 Family and Medical Leave Act, and was an outspoken liberal standard-bearer during a conservative-dominated era from the 1980s to the early 2000s.