BALTIMORE — Bulldozing entire neighborhoods to revitalize them seemingly went out of fashion decades ago, after the first mid-20th-century efforts at urban renewal were denounced as failures.

As it was, the neighborhood — a shooting location for the HBO series “The Wire” — stood in sharp contrast to the gentrifying neighborhoods of Butchers Hill and Canton to the south...

Now, the area, sometimes referred to as Middle East Baltimore, is re-emerging as the New East Baltimore, offering the promise of turning what had become an urban wasteland into a vibrant 88-acre community centered on a medical science and technology office park, which includes laboratory space.