In last few years, the growth of generic companies, slowdown in a new blockbuster drugs, patent cliff of top selling drugs and increased regulatory pressure are the key challenges for Pharma industry. Due to lack in innovation by research and development department many big pharma companies have started the generic subsidiaries. A generic industry is engaged in innovation, and this gives rise to supergenerics. Supergenerics come as a ray of hope for not only pharma business models but also for patients. To overcome the challenges faced by Pharma industry, the supergeneric will be the key player. Supergenerics assure the better quality at low cost and as strong alternative for biogenerics due to which many pharma industries are banking towards it. It is possible to develop the supergenerics within the regulatory and quality by design paradigm. The present review focuses all possible aspects of the supergenerics.