When a ritualistic elixir once held by the Mayapo natives of the Amazon rainforest is reformulated, Bren Williams, Derek O’Rourke and Russ Munroe unwittingly come into contact with the newfangled version at Prescott Chemicals. Shortly thereafter, the detectives experience a change to their body and minds with unalterable results. Although alarmed with their current predicament, all three master the formalities thus engendering them the power to complete their mission. With help from their experienced boss, an aggressive FBI agent, an eager journalist and a bitter French physicist, they quell the perpetrators, but not before one escapes with an undetermined amount of formula and a secret that could alter a detective’s life.