Fantasia on a Theme of Thomas Tallis is the story of Joe, a rich, handsome, womanizer who has it all but is still disillusioned with his life and the hypocritical people and society he has to deal with. He seeks spiritual fulfillment but cannot find it. At a fund raising party he has an argument over the question of illegal immigration. This is the last straw in an already shaky marriage and leads to his divorce. Joe, happy to be rid of his nagging wife but at the same time also sad at his divorce questions where his life is going. At a diabetes education class he is attending with his mother he meets an attractive woman. She proposes a date and after a disastrous encounter with her is even furthr disullusioned with humanity. At the same diabetes clinic he meets another woman, a poor Mexican immigrant with several health problems who is in a wheelchair. He is struck by her humbleness, intelligence, and beauty. Through her he begins to understand what true love means. She leads him to a spiritual reawakening through music, art, literature and most especially her love of life. Joe discards his previous lifestyle and learns to like her and then love her. Because of her he recognize the beauty inherent in  life while however, still maintaining a cynical view of humanity. Their love grows until it finally ends intragedy.