Mitty Andersen knows darn well that Bobby Tarleton didn’t die of a heroin overdose. They’d blown enough blues harmonica notes together for him to know that the rising blues star would never let anything get in the way of his music. So when he gets the news, in the middle of his blues set at Little Queenie’s, he suspects something evil came Bobby’s way. He aims to put his ex-investigative reporter skills to work to find out what happened and clear his friend’s good name.

It soon becomes apparent to Mitty that Bobby T just might be the latest in a string murders aimed at eliminating those that play the Devil’s music and he sets out to put an end to the madness before another harmonica player succumbs to the evil that has managed to avoid capture for way too long.

Mitty hits the blues circuit with his partner in chime, Pete Bolden, and rounds up a posse disguised as a blues band. They gig the juke joints and blues bars throughout Southeast Texas and Louisiana hoping to uncover the darkness that took Bobby T away and lure it into the light. They end up playing the gigs of their lives.