1938. New York City. A young woman hires The Chambers-Riggs Detective Agency to tail her husband, Simon Weiss, a comic strip artist and creator of the newest and hottest strip in the papers, The Adventures of Bucky Mars. They accept the job but soon realize that there's a lot more to Simon Weiss than what they see in the funny pages. A simple tail job pins Jack Chambers and Madison Riggs as pawns in a sinister game of deception and violence. Spanning from Hell's Kitchen to Long Island and into the darkest depths of Chinatown, they soon find out that everyone's on the take, everyone is connected and everyone wants them dead.

Murder has the last laugh in the gritty crime sequel to Shill for the Kill, where Blood Runs Deep...in the Gutter!