Volumetry of amygdala and hippocampus and memory performance in [An article from: Psychiatry Research: Neuroimaging [HTML] - available at Amazon. Note that other authors are noted there
Abstract: Magnetic resonance imaging (MRI) is showing increased utility in examining medial temporal lobe atrophy and its relationship to memory performance in Alzheimer's disease (AD). We studied 56 AD patients and 42 older healthy subjects with neuropsychological assessment and MRI. Hippocampal and amygdaloid volumes (normalized to intracranial volume) were contrasted between AD patients and healthy controls and correlated with neuropsychological performance. Comparisons between AD patients and healthy controls revealed highly significant differences in the normalized volume of hippocampus and amygdala by analysis of covariance. Group differences tended to be at least as large for amygdaloid as hippocampal volume, including when the subset of AD patients with the mildest symptoms was considered separately. Within the AD group, performance on the Memory-Orientation subscale of the Alzheimer's Disease Assessment Scale-Cognition (ADAS-Cog) was significantly correlated with normalized amygdaloid volume but not with normalized hippocampal volume. Other ADAS-Cog subscales (Language, Praxis) were uncorrelated with either volume. In the healthy control sample, neither hippocampal nor amygdaloid volumes were significant predictors of any neuropsychological measure. While a substantial literature continues to justify the focus on the hippocampus in MRI studies of AD, these results suggest that the amygdala should receive similar attention, including in studies of the prodromal stages of AD
The symbiotic pattern of evolution is everywhere and allows us a very different and fascinating window into the way symbiotic viruses work, since all viruses are symbiotic, including those involved in our human reproduction.
Where do viruses, such as Ebola and HIV, come from and why they are so aggressive? This book changed tenets of evolutionary virology, developing the concepts of aggressive symbiosis and plague culling, which explain much of the horror of plague virus
Our human genome is full of viruses similar to HIV-1. These have played an important role in human evolution and still play an important role in human embryology and day-to-day chemistry. Just how important are they to our evolution past and future?
